Single-cell resolution unravels spatial alterations in metabolism, transcriptome and epigenome of ageing liver

Nikopoulou C, Kleinenkuhnen N,  Parekh S, Sandoval T, Schneider F, Giavalisco P, Bozukova M, Vesting AJ, Altmüller J, Wunderlich T, Kondylis V, Tresch A and Tessarz P

Single organoid RNA-sequencing reveals high organoid-to-organoid variability

Gehling K, Parekh S, Schneider F, Kirchner M, Kondylis V, Nikopoulou C and Tessarz P

Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance

Demetriadou C, Raoukka A,  Charidemou E, Mylonas C, Michael C,  Parekh S, Koufaris C, Skourides P, Papageorgis P, Tessarz P and Kirmizis A

Chromatin Remodeling due to degradation of Citrate Carrier impairs osteogenesis of aged mesenchymal stem cells

Pouikli A, Parekh S, Maleszewska M, Baghdadi M, Tripodi I, Nikopoulou C, Folz-Donahue K, Hinze Y, Mesaros A, Hoez D, Giavalisco P, Dowell R, Partridge L and Tessarz P

Methylation of Q105 on histone H2A is part of a dynamic regulatory mechanism integrating metabolism with ribosome biogenesis through recruitment of Nhp2.

Mawer JSP, Massen J, Reichert C, Grabenhorst N, Mylonas C and Tessarz P

The RNA-binding protein Puf5 buffers mRNA levels against chromatin-mediated changes in nascent transcription.

Kochan DZ, Mawer JSP, Massen J, Tishinov K, Parekh S, Graef M, Spang A and Tessarz P

Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19

Theobald SJ, Simonis A, Georgomanolis T, Kreer C, Zehner M, Eisfeld HS, Motameny S, Fischer J, Albert MC, Malin JJ, Graeb J, Winter S, Sandaradura de Silva U, Pouikli A, David F, Böll B, Köhler P, Gruell H, Suàrez I, Hallek M, Fätkenheuer G, Jung N, Cornely OA, Lehmann C, Tessarz P, Altmüller J, Nürnberg P, Kashkar H, Klein F, Koch M, Rybniker J

Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle stem cell fate.

Allmeroth K, Kim CS, Annibal A, Pouikli A, Koester J,  Derisbourg MJ, Chacón-Martínez CA, Latza C, Antebi A, Tessarz P, Wickström SA and Denzel MS

Epigenetic alterations in stem cell ageing - a promising target for age-reversing interventions?

Pouikli A and Tessarz P

Metabolism and Chromatin: A Dynamic Duo that Regulates Development and Ageing

Pouikli A and Tessarz P

Ageing and sources of transcriptional heterogeneity.

Nikopoulou C, Parekh S and Tessarz P

NET-prism enables RNA polymerase-dedicated transcriptional interrogation at nucleotide resolution.

Mylonas C and Tessarz P

SIRT7-dependent deacetylation of fibrillarin controls H2A methylation and rRNA synthesis during the cell cycle.

Iyer-Bierhoff A, Krogh N, Tessarz P, Ruppert T, Nielsen H, Grummt I

Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells.

Mylonas C and Tessarz P (2018):

Histone modifications in Ageing and Lifespan regulation.

Maleszewska M, Mawer JSP, Tessarz P

Histone core modifications regulating nucleosome structure and dynamics.

Tessarz P and Kouzarides T

Glutamine methylation on histone H2A is an RNA Polymerase I dedicated modification.

Tessarz P, Santos-Rosa H, Robson S, Nelson C, Nielsen ML, Kouzarides T

Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins.

Kohl C, Tessarz P, von der Malsburg K, Zahn R, Bukau B, Mogk A

The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins.

Tessarz P, Mogk A, Bukau B

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation.

Tessarz P, Mogk A, Bukau B

Common and specific mechanisms of AAA+ proteins involved in protein quality control.

Mogk A, Haslberger T, Tessarz P, Bukau B

Novel insights into the mechanism of chaperone-assisted protein disaggregation.

Weibezahn J, Schlieker C, Tessarz P, Mogk A, Bukau B

Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

Weibezahn J, Tessarz P, Schlieker C, Zahn R, Maglica Z, Lee S, Zentgraf H,Weber-Ban EU,  Dougan DA, Tsai  FT, Mogk A, Bukau B

Substrate recognition by the AAA+ chaperone ClpB.

Schlieker C, Weibezahn J, Patzelt H, Tessarz  P, Strub C, Zeth K, Erbse A, Schneider-Mergener J, Chin JW, Schultz PG, Bukau B, Mogk A

Inhibition of ubiquitin/proteasome-dependent proteolysis in Saccharomyces cerevisiae by a Gly-Ala repeat.

Heessen S, Dantuma NP, Tessarz P, Jellne M, Masucci MG